Your skin is your body’s largest organ. It covers and protects your body. Your skin
Holds body fluids in, preventing dehydration
Keeps harmful microbes out, preventing infections
Helps you feel things like heat, cold, and pain
Keeps your body temperature even
Makes vitamin D when the sun shines on it
Anything that irritates, clogs, or inflames your skin can cause symptoms such as redness, swelling, burning, and itching. Allergies, irritants, your genetic makeup, and certain diseases and immune system problems can cause rashes, hives, and other skin conditions. Many skin problems, such as acne, also affect your appearance.
NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases
For more information on dermatology or #YaleMedicine, visit: https://www.yalemedicine.org/stories/rare-skin-problems-treatment-genetics.
We hear a lot about treatments for skin problems like an acne flare-up, a worrisome mole, or eczema. But there are also quite a few rare, severe skin conditions that can have a major impact on quality of life, whether because they are painful or make you self-conscious about your appearance. Also, skin disorders can affect other parts of the body as well. For instance, erythrokeratodermia-cardiomyopathy (EKC) syndrome is a condition that causes plaques to form on the skin and also heart abnormalities. And people with genetic skin diseases are much more likely to experience depression. “Most disorders have a genetic basis, and in skin diseases, it’s incredibly easy to see them,” says dermatologist Keith Choate, MD, PhD. The unique thing about skin diseases, he says, is that the entire skin is made up of the same cells, performing different roles depending on the location on the body. “When we find a mutation in a new gene, the first thing that we do is ask, ‘What is the normal function of this gene within the skin?”’ Dr. Choate uses genetics to diagnose and treat rare skin diseases. At Yale, over a dozen new genetic skin diseases have been defined, and in some cases, Dr. Choate’s group has been able to develop treatments for them. ac Video Rating: / 5
Decoding genetic skin disorders: lessons and new technologies
Air date: Wednesday, April 15, 2015, 3:00:00 PM
Category: WALS – Wednesday Afternoon Lectures
Runtime: 00:53:04
Description: NIH Director’s Wednesday Afternoon Lecture Series
The underlying molecular basis has been determined for more than 2,000 inherited monogenic disorders, of which at least 20 percent have cutaneous manifestations. The explosion of knowledge about genetics and genetic disease during the past 20 years has helped us to understand how gene changes translate into clinical manifestations. The current availability of whole exome sequencing (WES) is rapidly decoding rare genetic skin disorders, uncovering new causes, facilitating genotype-based diagnosis at a fraction of pre-next generation sequencing costs, and enabling new individualized therapies based on knowledge of the underlying gene mutation. Emerging therapeutic options include the use of topical gentamycin for “readthrough” of null mutations, replacement with recombinant protein, topical pathogenesis-based therapy for lipid biosynthesis defects, and cell-based therapies through grafting or stem cell transplantation. An exciting result of WES is the ability to decode somatic mosaic genetic disorders through the comparative analysis of DNA from a lesional skin biopsy and genomic DNA. Many of these mutations in mosaic disorders result from activation of the RAS or PI3K/AKT signaling pathways, allowing targeted topical therapy with small-molecule inhibitors or gene suppression. New technology, such as microneedles and topically applied nanoconjugate creams, promise to deliver antisense DNA or siRNA through the epidermal barrier to skin targets. Clinically normal skin in generalized recessive skin disorders may represent sites of revertant mosaicism, allowing expansion of the patient’s own phenotypically normal cells as replacement of abnormal cells with the risk of immune rejection. These therapeutic options, together with the plummeting cost of technology, will revolutionize our ability to provide personalized therapy for patients with genetic skin disorders.
For more information go to http://wals.od.nih.gov
Author: Amy S. Paller, M.S., M.D., Walter J. Hamlin Professor and Chair, Department of Dermatology; Professor, Department of Pediatrics, and Director, Skin Disease Research Center, Northwestern University Feinberg School of Medicine
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One of our biggest nightmare is to wake in the morning and see that pimple on your face. Let’s face it that everyone of us go through the phase in life when your biggest problem in life is get rid of those pimples and get back your clear skin.
It’s not a secret that you really need to take care of your skin and treat pimples carefully because if you don’t treat them well than it can lead to skin damages, ugly scars etc. There are several treatments available in the market but its always better to go for natural treatment to avoid any side effects. In this tutorial I’ll be sharing some really amazing home remedies (3-steps process) to get rid of pimples overnight.
Products used/shown in this video –
STEP# 1 SUPPRESS
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ICE
STEP# 2 SPOT TREATMENT
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Option 1# 1 Drop Of Tea Tree Oil
Option 2# 3 Drops Of Lemon + 1/2 Tea Spoon Honey
Option 3# 1/2 Tea Spoon Potato Juice + 1 Pinch Cinnamon Powder
Option 4# 1 Drop Raw Papaya Juice
STEP# 3 HEALING
—————————–
1/2 Tea Spoon Aloe Vera Gel
2-3 Mint Leaves
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DISCLAIMER: The information provided on this channel and its videos is for general purposes only and should NOT be considered as professional advice. We always try our best to provide accurate information and sound advice but please note that we are not a licensed professional or a medical practitioner so always make sure you consult a professional in case of need. All products/services reviewed on this channel have been purchased by me unless stated otherwise. We always try to keep our channel and its content updated but we cannot guarantee it. All opinions expressed here are our own and we are not compensated by any brand, advertiser, PR representative or affiliate for the same unless explicitly stated in our videos and/or description box. We never try to push products on anyone but we do make recommendations based on our personal experience. All the content published on this channel is our own creative work and is protected under copyright law and in case you need to use our content for any purpose please write to us – contactus@shrutiarjunanand.com * Video Rating: / 5
I had a consultation at Banobagi Dermatology in Korea and 00 worth of skin care treatments! Was it worth it?!
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DERMAPLANING SKIN TREATMENT AT HOME | BEFORE AND AFTER RESULTS
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Today iI’m showing you my amazing skincare secret to clear skin! So I’ve been shaving my face for years, and I just recently learned what the technical term is for shaving your face: dermaplaning. Dermaplaning basically makes your skin incredibly smooth (it’s like getting a facial) by removing all the peach fuzz of your face as well as the d e a d skin. After dermaplaning/shaving your face, your skin is left super smooth.
▶︎Tips For Dermaplaning
1. Be very gentle when shaving your face.
2. Wipe off/clean off your razor as you go.
3. No makeup 24-48 hours after you dermaplane/shave.
4. Use a new razor every time.
5. Stay hydrated for clearer skin!
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